منابع مشابه
Quantitative evaluation of abscopal effect based on biological effective dose in breast cancer tumors in mice
Background: Due to abscopal effect, cell damage may occur outside of the radiation field and the quantification of this effect is one of the most challenging debates in radiation therapy. The aim of this study was to estimate the abscopal effect induced in non-irradiated tumors quantitatively by means of biological effective dose (BED). Materials and Methods: Breast tumors using 4T1 and MC4-L2 ...
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Testicular interstitial cell tumors have appeared in estrogen-treated mice of at least three different inbred strains (1, 2, 11, 12, 13, 21), rarely in those of other strains treated in a comparable manner (2, 11, 21). Spontaneous testicular tumors were not described in those inbred strains that acquired such tumors subsequent to prolonged treatment with estrogens. In fact such tumors occur rar...
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Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more different...
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A total of 305 female and 36 male SENCAR mice in six different groups were observed for 540 to 875 days for tumors as well as nonneoplastic lesions. Three of these groups were observed for their lifespans. The 123 females and 36 males, observed for their lifespans (800 to 875 days) showed median survival times ranging from 730 to 745 days. The average peak body weights were 42.4 g for females a...
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wnloaded ough nonsteroidal anti-inflammatory drugs (NSAID), including sulindac, have been used extenas chemopreventive agents for colorectal cancer, results are not consistent. NSAIDs, most reportedly ac, often do not cause a complete regression of adenomas and some patients develop resistance to treatment. In this study, we evaluated the effect of sulindac on colon tumorigenesis in the Apc e m...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2003
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1207275